("Flip-flop" with respect to parent drug absorption kinetics) % 0 C7 Time, min Fic. Dosberoende kinetik resul te- rar iven krokt linge enligt "8".
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when the ka (absorption constant) is slower than ke (elimination constant). These circumstances can occur with sustained-release formulations, depo IM injections, and some subcutaneous or intradermal injections. Flip-flop kinetics refers to a situation when the rate of absorption of a compound is significantly slower than its rate of elimination from the body. The persistence of the compound in the body therefore becomes dependent on absorption rather than elimination processes (Fig.
These circumstances can occur with sustained-release formulations, depo IM injections, and some subcutaneous or intradermal injections. Define flip-flop kinetics. Flip-flop kinetics refers to a situation when the rate of absorption of a compound is significantly slower than its rate of elimination from the body. The persistence of the compound in the body therefore becomes dependent on absorption rather than elimination processes ( Fig. 2.10 ). Flip-flop kinetics. In pharmacokinetics, flip-flop phenomenon happens when a drug is released at a sustained rate instead of immediate release, such as sustained-release formulation v.s. immediate-release formulation (tablet, IV). Additional recommended knowledge.
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av E Fredriksson · 2020 — Detta fenomen brukar kallas ”flip flop”, absorptionen efter SC administration är så långsam att den påverkar T1/2, i detta fall till den grad att den inte går att
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Pharmacokinetic Tricks and Traps: Flip-Flop Models. In the analysis of extra-vascular plasma concentration-time profiles, the disentanglement of influences from disposition and absorption rate influences is often challenging. This can be particularly true when absorption is considerably slower than disposition, that is, in a " flip-flop " system. The term flip – flop is used as they can switch between the states under the influence of a control signal (clock or enable) i.e.
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The persistence of the compound in the body therefore becomes dependent on absorption rather than elimination processes (Fig. 2.10). This sometimes occurs when the route of exposure is dermal. Flip-flop kinetics In pharmacokinetics, flip-flop phenomenon happens when a drug is released at a sustained rate instead of immediate release, such as sustained-release formulation v.s. immediate-release formulation (tablet, IV). Weighing the Right Way Flip-flop kinetics occurs when the absorption rate is slower than the elimination rate.